Hereditary Breast & Ovarian Cancer Panel
Genes and variants most often included on clinical hereditary breast and ovarian cancer (HBOC) multi-gene panels, spanning BRCA1/BRCA2 and the other DNA-damage-repair genes tested alongside them.
8 genes · 3 variants
BRCA1 DNA repair associated
BRCA1 is a human protein-coding gene.
BRCA2 DNA repair associated
BRCA2 is a human protein-coding gene.
partner and localizer of BRCA2
PALB2 is a human protein-coding gene.
ATM serine/threonine kinase
ATM is a human protein-coding gene.
checkpoint kinase 2
CHEK2 is a human protein-coding gene.
RAD51 paralog C
RAD51C is a human protein-coding gene.
RAD51 paralog D
RAD51D is a human protein-coding gene.
BRCA1 interacting DNA helicase 1
BRIP1 is a human protein-coding gene.
BRCA1 · p.Gln1756Profs
rs80357906 is a genetic variant located in the BRCA1 gene.
BRCA1 · p.Ala1708Glu
rs28897696 is a genetic variant located in the BRCA1 gene.
BRCA2 · p.Ser1982fs
rs80359550 is a genetic variant located in the BRCA2 gene.
Educational information only — not medical advice, a diagnosis, or a clinical recommendation. This panel is a curated grouping of public-record gene and variant pages for reference; it does not reflect your own genome or personal risk. Consult a qualified genetics professional or genetic counselor for interpretation relevant to you.