rs7412
NM_000041.2(APOE):c.526C>T (p.Arg176Cys)
- atorvastatin response - EfficacyDrug response · ★★★ · germline
- HypercholesterolemiaBenign · ★ · unknown
- Familial type 3 hyperlipoproteinemiaPathogenic · germline
- Hyperlipoproteinemia due to APOE1Pathogenic · germline
- Warfarin responseDrug response · unknown
- Familial type 3 hyperlipoproteinemiano classifications from unflagged record · germline
- not providedRisk factor · ★★ · germline
- not specifiedUncertain significance · ★ · germline
- not specifiedBenign · germline
gnomAD allele frequency 8.27e-2
rs7412 is a genetic variant located in the APOE gene. dbsnp · gene
In gnomAD, rs7412 has an overall allele frequency of 8.3%. gnomad · frequency
In ClinVar, rs7412 is classified as Drug response (efficacy) for atorvastatin response (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs7412 is classified as Benign for Hypercholesterolemia (1 review star; last evaluated 2019-01-01). clinvar · classificationclinvar · review confidenceclinvar · assertion date
In ClinVar, rs7412 is classified as Pathogenic for Familial type 3 hyperlipoproteinemia (0 review stars, germline; last evaluated 2017-02-21). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs7412 is classified as Pathogenic for Hyperlipoproteinemia due to APOE1 (0 review stars, germline; last evaluated 1984-04-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs7412 is classified as Drug response for Warfarin response (0 review stars; last evaluated 2010-08-31). clinvar · classificationclinvar · review confidenceclinvar · assertion date
In ClinVar, rs7412 is classified as no classifications from unflagged record for Familial type 3 hyperlipoproteinemia (0 review stars, germline; last evaluated 2025-01-06). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs7412 is classified as Risk factor for not provided (2 review stars, germline; last evaluated 2023-08-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs7412 is classified as Uncertain significance for not specified (1 review star, germline; last evaluated 2019-01-18). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs7412 is classified as Benign for not specified (0 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
retrieved 2026-08-03 · facts 1138244658804bc3 · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0
Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.