rs67376798
NM_000110.4(DPYD):c.2846A>T (p.Asp949Val)
- fluorouracil response - ToxicityDrug response · ★★★ · germline
- fluorouracil response - OtherDrug response · ★★★ · germline
- capecitabine response - ToxicityDrug response · ★★★ · germline
- tegafur response - ToxicityDrug response · ★★★ · germline
- Dihydropyrimidine dehydrogenase deficiency (DPYDD)Likely pathogenic · ★★ · unknown
- DPYD-related disorderPathogenic · ★ · paternal
- Inborn genetic diseasesUncertain significance · ★ · germline
- Fluorouracil responseother · germline
- not providedConflicting interpretations · ★ · unknown
gnomAD allele frequency 3.25e-3
rs67376798 is a genetic variant located in the DPYD gene. dbsnp · gene
In gnomAD, rs67376798 has an overall allele frequency of 0.32%. gnomad · frequency
In ClinVar, rs67376798 is classified as Drug response (toxicity) for fluorouracil response (3 review stars, germline; last evaluated 2021-05-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs67376798 is classified as Drug response for fluorouracil response - Other (3 review stars, germline; last evaluated 2021-05-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs67376798 is classified as Drug response (toxicity) for capecitabine response (3 review stars, germline; last evaluated 2021-05-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs67376798 is classified as Drug response (toxicity) for tegafur response (3 review stars, germline; last evaluated 2021-05-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs67376798 is classified as Likely pathogenic for Dihydropyrimidine dehydrogenase deficiency (DPYDD) (2 review stars; last evaluated 2024-07-11). clinvar · classificationclinvar · review confidenceclinvar · assertion date
In ClinVar, rs67376798 is classified as Pathogenic for DPYD-related disorder (1 review star, paternal; last evaluated 2024-01-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs67376798 is classified as Uncertain significance for Inborn genetic diseases (1 review star, germline; last evaluated 2016-11-08). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs67376798 is classified as other for Fluorouracil response (0 review stars, germline; last evaluated 2016-02-29). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs67376798 is classified as Conflicting interpretations for not provided (1 review star; last evaluated 2024-08-01). clinvar · classificationclinvar · review confidenceclinvar · assertion date
retrieved 2026-08-03 · facts 088d8ba9dd0ae706 · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0
Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.