rs4680
NM_000754.4(COMT):c.472G>A (p.Val158Met)
- Schizophrenia (SCZD)Benign · ★ · germline
- Tramadol responseDrug response · somatic
- CATECHOL-O-METHYLTRANSFERASE POLYMORPHISMBenign · germline
- not specifiedBenign · ★ · germline
- not providedBenign · ★ · germline
gnomAD allele frequency 4.49e-1
rs4680 is a genetic variant located in the COMT gene. dbsnp · gene
In gnomAD, rs4680 has an overall allele frequency of 44.9%. gnomad · frequency
In ClinVar, rs4680 is classified as Benign for Schizophrenia (SCZD) (1 review star, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs4680 is classified as Drug response for Tramadol response (0 review stars, somatic; last evaluated 2018-04-28). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs4680 is classified as Benign for CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM (0 review stars, germline; last evaluated 2011-01-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs4680 is classified as Benign for not specified (1 review star, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs4680 is classified as Benign for not provided (1 review star, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
retrieved 2026-08-03 · facts 11cbcf1cc431e7cd · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0
Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.