rs4244285
NM_000769.4(CYP2C19):c.681G>A (p.Pro227=)
- Clopidogrel responseDrug response · ★★★★ · germline
- Citalopram responseDrug response · ★★★★ · germline
- Escitalopram responseDrug response · ★★★★ · germline
- Sertraline responseDrug response · ★★★★ · germline
- Voriconazole responseDrug response · ★★★★ · germline
- CYP2C19: no functionDrug response · ★★★★ · germline
- Mephenytoin, poor metabolism ofDrug response · germline
- Proguanil, poor metabolism ofDrug response · germline
- not providedLikely benign · ★★ · germline
- not specifiedLikely benign · ★ · germline
gnomAD allele frequency 1.67e-1
rs4244285 is a genetic variant located in the CYP2C19 gene. dbsnp · gene
In gnomAD, rs4244285 has an overall allele frequency of 16.7%. gnomad · frequency
In ClinVar, rs4244285 is classified as Drug response for Clopidogrel response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs4244285 is classified as Drug response for Citalopram response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs4244285 is classified as Drug response for Escitalopram response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs4244285 is classified as Drug response for Sertraline response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs4244285 is classified as Drug response for Voriconazole response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs4244285 is classified as Drug response for CYP2C19: no function (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs4244285 is classified as Drug response for Mephenytoin, poor metabolism of (0 review stars, germline; last evaluated 2009-06-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs4244285 is classified as Drug response for Proguanil, poor metabolism of (0 review stars, germline; last evaluated 2009-06-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs4244285 is classified as Likely benign for not provided (2 review stars, germline; last evaluated 2018-08-07). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs4244285 is classified as Likely benign for not specified (1 review star, germline; last evaluated 2018-03-09). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
retrieved 2026-08-03 · facts ef82d89442a824b4 · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0
Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.