← Genclarus

rs4149056

NM_006446.5(SLCO1B1):c.521T>C (p.Val174Ala)

SLCO1B1missense variantp.Val174Alasingle nucleotide variant
ClinVar by condition
  • atorvastatin response - Metabolism/PKDrug response · ★★★ · germline
  • lovastatin response - ToxicityDrug response · ★★★ · germline
  • pitavastatin response - Metabolism/PKDrug response · ★★★ · germline
  • pravastatin response - ToxicityDrug response · ★★★ · germline
  • simvastatin response - Metabolism/PKDrug response · ★★★ · germline
  • fluvastatin response - Metabolism/PKDrug response · ★★★ · germline
  • fluvastatin response - ToxicityDrug response · ★★★ · germline
  • lovastatin acid response - Metabolism/PKDrug response · ★★★ · germline
  • lovastatin response - Metabolism/PKDrug response · ★★★ · germline
  • rosuvastatin response - ToxicityDrug response · ★★★ · germline
  • simvastatin response - ToxicityDrug response · ★★★ · germline
  • atorvastatin response - ToxicityDrug response · ★★★ · germline

gnomAD allele frequency 1.36e-1

rs4149056 is a genetic variant located in the SLCO1B1 gene. dbsnp · gene

In gnomAD, rs4149056 has an overall allele frequency of 13.6%. gnomad · frequency

In ClinVar, rs4149056 is classified as Drug response for atorvastatin response - Metabolism/PK (3 review stars, germline; last evaluated 2022-02-15). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response (toxicity) for lovastatin response (3 review stars, germline; last evaluated 2022-02-15). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response for pitavastatin response - Metabolism/PK (3 review stars, germline; last evaluated 2022-02-15). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response (toxicity) for pravastatin response (3 review stars, germline; last evaluated 2022-02-15). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response for simvastatin response - Metabolism/PK (3 review stars, germline; last evaluated 2022-02-14). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response for fluvastatin response - Metabolism/PK (3 review stars, germline; last evaluated 2022-02-10). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response (toxicity) for fluvastatin response (3 review stars, germline; last evaluated 2022-02-10). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response for lovastatin acid response - Metabolism/PK (3 review stars, germline; last evaluated 2022-02-10). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response for lovastatin response - Metabolism/PK (3 review stars, germline; last evaluated 2022-02-10). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response (toxicity) for rosuvastatin response (3 review stars, germline; last evaluated 2022-02-10). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response (toxicity) for simvastatin response (3 review stars, germline; last evaluated 2021-04-07). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response (toxicity) for atorvastatin response (3 review stars, germline; last evaluated 2021-04-07). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response for simvastatin acid response - Metabolism/PK (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response for rosuvastatin response - Metabolism/PK (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Drug response (toxicity) for hmg coa reductase inhibitors response (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Benign for Rotor syndrome (HBLRR) (2 review stars, germline; last evaluated 2024-11-29). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Pathogenic for Gilbert syndrome (0 review stars, inherited; last evaluated 2019-05-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Likely benign for SLCO1B1-related disorder (0 review stars, germline; last evaluated 2021-07-21). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Benign for not provided (2 review stars, germline; last evaluated 2018-03-14). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs4149056 is classified as Benign for not specified (0 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin

Sources

retrieved 2026-08-03 · facts 67869029efd75a2e · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0

Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.