rs3745274
NM_000767.5(CYP2B6):c.516G>T (p.Gln172His)
- efavirenz response - Metabolism/PKDrug response · ★★★ · germline
- efavirenz response - ToxicityDrug response · ★★★ · germline
- nevirapine response - Metabolism/PKDrug response · ★★★ · germline
- Efavirenz responseDrug response · germline
- CYP2B6-related disorderLikely benign · germline
gnomAD allele frequency 2.63e-1
rs3745274 is a genetic variant located in the CYP2B6 gene. dbsnp · gene
In gnomAD, rs3745274 has an overall allele frequency of 26.3%. gnomad · frequency
In ClinVar, rs3745274 is classified as Drug response for efavirenz response - Metabolism/PK (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs3745274 is classified as Drug response (toxicity) for efavirenz response (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs3745274 is classified as Drug response for nevirapine response - Metabolism/PK (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs3745274 is classified as Drug response for Efavirenz response (0 review stars, germline; last evaluated 2015-05-18). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs3745274 is classified as Likely benign for CYP2B6-related disorder (0 review stars, germline; last evaluated 2021-07-22). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
retrieved 2026-08-03 · facts 28bbace56c8a630d · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0
Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.