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rs34637584

NM_198578.4(LRRK2):c.6055G>A (p.Gly2019Ser)

LRRK2missense variantp.Gly2019Sersingle nucleotide variant
ClinVar by condition
  • Autosomal dominant Parkinson disease 8Likely pathogenic · ★★ · germline
  • Parkinson disease (PD)Pathogenic · ★ · germline
  • Inborn genetic diseasesPathogenic · ★ · germline
  • Parkinson disease, late-onset (PD)Pathogenic · ★ · germline
  • Young-onset Parkinson diseaseRisk factor · ★ · germline
  • LRRK2-related disorderPathogenic · germline
  • not providedPathogenic · ★★ · germline

gnomAD allele frequency 1.91e-4

rs34637584 is a genetic variant located in the LRRK2 gene. dbsnp · gene

In gnomAD, rs34637584 has an overall allele frequency of 0.02%. gnomad · frequency

In ClinVar, rs34637584 is classified as Likely pathogenic for Autosomal dominant Parkinson disease 8 (2 review stars, germline; last evaluated 2025-01-17). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs34637584 is classified as Pathogenic for Parkinson disease (PD) (1 review star, germline; last evaluated 2023-03-30). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs34637584 is classified as Pathogenic for Inborn genetic diseases (1 review star, germline; last evaluated 2022-07-19). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs34637584 is classified as Pathogenic for Parkinson disease, late-onset (PD) (1 review star, germline; last evaluated 2021-05-03). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs34637584 is classified as Risk factor for Young-onset Parkinson disease (1 review star, germline; last evaluated 2017-12-29). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs34637584 is classified as Pathogenic for LRRK2-related disorder (0 review stars, germline; last evaluated 2024-09-04). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

In ClinVar, rs34637584 is classified as Pathogenic for not provided (2 review stars, germline; last evaluated 2024-10-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date

Sources

retrieved 2026-08-03 · facts 02b735f5d8eb0b6e · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0

Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.