rs1800629
NC_000006.12:g.31575254G>A
- etanercept response - EfficacyDrug response · ★★★ · germline
- Systemic lupus erythematosus, susceptibility toRisk factor · germline
- Inherited susceptibility to asthmaRisk factor · germline
- Malaria, cerebral, susceptibility toRisk factor · germline
- HUMAN IMMUNODEFICIENCY VIRUS DEMENTIA, SUSCEPTIBILITY TORisk factor · germline
- Psoriatic arthritis, susceptibility toRisk factor · germline
- Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF, TNFR, and/or TNFR4Uncertain significance · germline
- Susceptibility to severe coronavirus disease (COVID-19)Uncertain significance · germline
- EndometriosisAffects · somatic
gnomAD allele frequency 1.47e-1
rs1800629 is a genetic variant located in the TNF gene. dbsnp · gene
In gnomAD, rs1800629 has an overall allele frequency of 14.7%. gnomad · frequency
In ClinVar, rs1800629 is classified as Drug response (efficacy) for etanercept response (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs1800629 is classified as Risk factor for Systemic lupus erythematosus, susceptibility to (0 review stars, germline; last evaluated 2006-03-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs1800629 is classified as Risk factor for Inherited susceptibility to asthma (0 review stars, germline; last evaluated 2006-03-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs1800629 is classified as Risk factor for Malaria, cerebral, susceptibility to (0 review stars, germline; last evaluated 2006-03-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs1800629 is classified as Risk factor for HUMAN IMMUNODEFICIENCY VIRUS DEMENTIA, SUSCEPTIBILITY TO (0 review stars, germline; last evaluated 2006-03-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs1800629 is classified as Risk factor for Psoriatic arthritis, susceptibility to (0 review stars, germline; last evaluated 2006-03-01). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs1800629 is classified as Uncertain significance for Susceptibility to severe coronavirus disease (COVID-19) due to high plasma levels of TNF, TNFR, and/or TNFR4 (0 review stars, germline; last evaluated 2021-08-07). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs1800629 is classified as Uncertain significance for Susceptibility to severe coronavirus disease (COVID-19) (0 review stars, germline; last evaluated 2021-02-09). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs1800629 is classified as Affects for Endometriosis (0 review stars, somatic; last evaluated 2021-10-20). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
retrieved 2026-08-03 · facts 62eb3a9a857a62dc · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0
Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.