rs16969968
NM_000745.4(CHRNA5):c.1192G>A (p.Asp398Asn)
- nicotine response - ToxicityDrug response · ★★★ · germline
- Lung cancer susceptibility 2 (LNCR2)Risk factor · germline
- SMOKING AS A QUANTITATIVE TRAIT LOCUS 3 (SQTL3)Risk factor · germline
- Susceptibility to severe coronavirus disease (COVID-19) due to high levels of fibrinogen and C-reactive proteinUncertain significance · germline
gnomAD allele frequency 2.41e-1
rs16969968 is a genetic variant located in the CHRNA5 gene. dbsnp · gene
In gnomAD, rs16969968 has an overall allele frequency of 24.1%. gnomad · frequency
In ClinVar, rs16969968 is classified as Drug response (toxicity) for nicotine response (3 review stars, germline; last evaluated 2021-03-24). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs16969968 is classified as Risk factor for Lung cancer susceptibility 2 (LNCR2) (0 review stars, germline; last evaluated 2010-07-27). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs16969968 is classified as Risk factor for SMOKING AS A QUANTITATIVE TRAIT LOCUS 3 (SQTL3) (0 review stars, germline; last evaluated 2010-07-27). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
In ClinVar, rs16969968 is classified as Uncertain significance for Susceptibility to severe coronavirus disease (COVID-19) due to high levels of fibrinogen and C-reactive protein (0 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
retrieved 2026-08-03 · facts db0d5b4967863177 · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0
Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.