rs12248560
NM_000769.1(CYP2C19):c.-806C>T
- CYP2C19: increased functionDrug response · ★★★★ · germline
- Clopidogrel responseDrug response · ★★★★ · germline
- Citalopram responseDrug response · ★★★★ · germline
- Escitalopram responseDrug response · ★★★★ · germline
- Sertraline responseDrug response · ★★★★ · germline
- Voriconazole responseDrug response · ★★★★ · germline
- CYP2C19: no functionDrug response · ★★★★ · germline
- not providedBenign · ★★ · germline
gnomAD allele frequency 2.05e-1
rs12248560 is a genetic variant located in the CYP2C19 gene. dbsnp · gene
In gnomAD, rs12248560 has an overall allele frequency of 20.5%. gnomad · frequency
In ClinVar, rs12248560 is classified as Drug response for CYP2C19: increased function (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs12248560 is classified as Drug response for Clopidogrel response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs12248560 is classified as Drug response for Citalopram response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs12248560 is classified as Drug response for Escitalopram response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs12248560 is classified as Drug response for Sertraline response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs12248560 is classified as Drug response for Voriconazole response (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs12248560 is classified as Drug response for CYP2C19: no function (4 review stars, germline). clinvar · classificationclinvar · review confidenceclinvar · origin
In ClinVar, rs12248560 is classified as Benign for not provided (2 review stars, germline; last evaluated 2018-03-14). clinvar · classificationclinvar · review confidenceclinvar · originclinvar · assertion date
retrieved 2026-08-03 · facts 72448eb74f483db6 · meta/llama-3.1-8b-instruct · prompt 4.0.1 · schema 3.0.0
Educational information only — not medical advice, a diagnosis, or a clinical interpretation. A variant's significance can be uncertain, conflicting, or dependent on your full clinical and family context. Consult a qualified genetics professional or genetic counselor before drawing any conclusion.